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This project will sequence 100,000 whole genomes from about 70,000 NHS patients with either certain types of cancer or patients with rare disease plus their families.
With consent patients’ genomes will be sequenced and linked to details about an individual’s medical condition. Doing this may help medical teams provide better diagnosis or treatment in some cases. In other cases, not enough may yet be known about a particular cancer or rare disease to interpret an individual’s data.
By adding key information from medical records, and securely collating data, scientists can compare tens, hundreds or even thousands of people with the same rare condition. Allowing approved scientists to have monitored access to this data will improve our understanding of ill health and how to treat it.
Aims of the project
What is happening locally?
The 100,000 genomes project is run by 13 Genomics Medicine Centres including Wessex Genomics Medicine Centre (WGMC) hosted by University Hospital Southampton NHS Foundation Trust. The hospitals in Portsmouth, Winchester, Basingstoke and Bournemouth are also working in partnership with WGMC to recruit patients and collect tissue samples.
Once consent is given, samples are collected from patients and appropriate family members. DNA is extracted locally, and sent for sequencing at the central facilities near Cambridge. The results are sent back to WGMC where clinical geneticists discuss relevant findings with patients and their families.
Working with their local partner hospitals, WGMC will recruit 5000 patients with either a rare disease or cancer.
Wessex AHSN supports Wessex GMC in implementing the 100,000 genomes project. We have helped surrounding hospitals to join as partners in finding and recruiting appropriate patients, and have organised meetings and events to ensure public, patients and clinicians have chance to understand, engage and participate in this transformational project.
If you would like to take part in the 100,000 genome project, find out more from University Hospital Southampton.
“This project has the potential to transform the future of healthcare and we are delighted many patients from across the south can be involved and will benefit from it. It will improve the prediction and prevention of disease, enable new and more precise diagnostic tests and allow personalisation of drugs and other treatments to specific genetic variants.”
Professor Karen Temple, clinical geneticist, UHS; co-lead, Wessex NHS GMC
UHS Clinical Research update - Issue 5, Autumn 2015
WESSEX GMC BULLETIN August 2016.docx