Model of care for testing populations to identify individuals at higher risk of breast and ovarian cancers because they carry the BRCA1/2 genes
Testing for breast cancer gene mutations (BRCA) is currently only offered to women based on clinical criteria or family history of cancer. This approach misses over half at-risk BRCA carriers, which can be overcome by offering BRCA-testing to everyone irrespective of family history.
Population Genetic Testing offers unselected testing for BRCA mutations with an initial focus on a high-risk Ashkenazi Jewish population where 1 in 40 individuals carry specific faults in BRCA1/BRCA2 genes.
Carrying out BRCA-testing on this population (proven to identify over 50% additional BRCA carriers), and identifying those at risk, can enable early detection and prevention of breast and ovarian cancers.
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